Record Display for the EPA National Library CatalogRECORD NUMBER: 5 OF 20
|Main Title||Delayed Reproductive Effects Following Exposure to Toxic Chemicals during Critical Developmental Periods.|
|Author||Gray, L. E. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Reproduction(Biology) ; Morphology ; Pathology ; Androgens ; Estrogens ; Progestational hormones ; Rodents ; Humans ; Males ; Females ; Toxic substances ; Prenatal exposure delayed effects ; Diethylstilbestrol|
The studies presented in the review indicate that perinatal exposure of the fetal or neonatal rodent to a toxicant can adversely affect reproductive development, reduce fertility and accelerate reproductive senescence. In rodents and humans exposure to DES, estrogens, androgens and progestins during critical developmental periods produce morphological and pathological alterations of the reproductive tract of males and females. DES treatment causes cancer, infertility and serious morphological abnormalities of the reproductive tract in all species examined.