Record Display for the EPA National Library Catalog


Main Title A short-term method for assessing the reproductive toxicity of endocrine-disrupting chemicals using the fathead minnow (Pimephales promelas) /
Author Mid-Continent Ecology Division.
CORP Author National Health and Environmental Effects Research Lab., Duluth, MN. Mid-Continent Ecology Div. (Duluth) Library.
Publisher National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 2002
Report Number EPA/600-R-01-067
Stock Number PB2007-106215
OCLC Number 50549562
Subjects Endocrine disrupting chemicals--Toxicology. ; Fathead minnow. ; Reproductive toxicology.
Additional Subjects Reproductive toxicity ; Assessment ; Fathead minnow ; Manuals ; Test methods ; Chemicals ; Estrogens ; Androgens ; Endpoint ; Reproductive behavior ; Fecuncity ; Fertility ; Procedures ; Measurements ; Short-term test method ; Endocrine-disrupting chemicals ; Endocrine pathways ; Adult survival ; Secondary sex characteristics ; Gonadosomatic ; Gonadal histology ; Plasma concentrations ; Vitellogenin ; Sex steroids
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EIAD  EPA/600/R-01/067 Region 2 Library/New York,NY 04/21/2006 DISPERSAL
EJBD ARCHIVE EPA 600-R-01-067 Headquarters Library/Washington,DC 11/17/2015
EJBD  EPA 600-R-01-067 Headquarters Library/Washington,DC 11/18/2015
EKCD  EPA/600/R-01/067 CEMM/GEMMD Library/Gulf Breeze,FL 08/12/2013
ELDD  EPA/600/R-01/067 CCTE/GLTED Library/Duluth,MN 09/06/2002
NTIS  PB2007-106215 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xi, 154 pages : illustrations ; 28 cm
This manual describes a test method with the fathead minnow suitable for assessing potential reproductive effects of chemicals, with an emphasis on endocrine pathways controlled by estrogens and androgens. The test is conducted with reproductively-mature animals for 21 d. Endpoints assessed include: adult survival, reproductive behavior, secondary sex characteristics, gonadosomatic index, gonadal histology, plasma concentrations of vitellogenin and sex steroids (beta-estradiol, testosterone, 11-ketotestosterone), fecundity, fertility, and if desired, F(sub 1) viability. In addition to describing the test method, guidance is presented as to interpretation of test results with respect to identifican of potential endocrine-disrupting chemicals.
"June 2002." Includes bibliographical references (pages 98-107). "EPA/600-R-01-067." Includes appendices "A-E" (p. 108-147).