Record Display for the EPA National Library Catalog


Main Title Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis : an assessment of the biological and epidemiological evidence /
Author Ahlborg, Ulf G.,
Other Authors
Author Title of a Work
Lipworth, Loren.,
Titus-Ernstoff, Linda.,
Hsieh, Chung-Cheng.,
Hanberg, Annika.,
Baron, John.,
Trichopoulos, Dimitrios.,
Adami, Hans-Olov.,
Publisher CRC Press, Inc.,
Year Published 1995
OCLC Number 878677675
Subjects Breast--Cancer--United States ; Pesticides--Environmental aspects ; Pesticide residues in food--United States ; Pesticides--Physiological effect--United States ; Estrogen--Physiological effect ; Insect chemosterilization--United States ; Pesticides--Environmental aspects--United States ; Organochlorine compounds--Toxicology ; Pesticides--United States--Physiological effect
Library Call Number Additional Info Location Last
ESAM  RC280.B8.O74 1995 Region 10 Library/Seattle,WA 05/06/2014
Collation 68 unnumbered pages : illustrations ; 28 cm
Includes bibliographical references (pages 515-531) Caption title.
Contents Notes
There is an increasing public and scientific concern that certain chlorinated compounds, recognized as environmental pollutants, may cause estrogen-related neoplastic disease in humans. The main hypothesis has been that certain organochlorines, through their estrogenic actions, might cause breast cancer. From experimental studies, both in vitro and in vivo, there is evidence that certain organochlorine compounds may cause estrogenic effects, whereas others may cause antiestrogenic effects. In limited studies, some of these compounds in high doses have also been shown to increase and reduce the frequency of estrogen-related tumors in animals. The epidemiological findings regarding the association between organochlorines and breast cancer are inconclusive. However, the largest and best designed study has been interpreted as negative with respect to DDT and polychlorinated biphenyls (PCB) in relation to breast cancer. Associations between organochlorine exposure and endometrial cancer or endometriosis have even more limited empirical basis. The hypothesis that human exposure to environmental levels of organochlorines would favor an estrogenic overactivity leading to an increase in estrogen-dependent formation of mammary or endometrial tumors is not supported by the existing in vitro, animal and epidemiological evidence. It can, however, not be conclusively rejected on the basis of available data.