Record Display for the EPA National Library Catalog

RECORD NUMBER: 3 OF 6

OLS Field Name OLS Field Data
Main Title Norepinephrine Decreases EGF (Epidermal Growth Factor) Binding in Primary Rat Hepatocyte Cultures.
Author Cruise, J. L. ; Cotecchia, S. ; Michalopoulos, G. ;
CORP Author Duke Univ. Medical Center, Durham, NC. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC.;National Institutes of Health, Bethesda, MD.
Year Published 1986
Report Number EPA-CR-811687; EPA/600/J-86/455;
Stock Number PB88-185566
Additional Subjects Norepinephrine ; Cells(Biology) ; Rats ; Laboratory animals ; Reprints ; Epidermal growth factor-Urogastrone ; Receptors(Adrenergic) ; DNA ; Phosphoinositides
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB88-185566 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/04/1988
Collation 8p
Abstract
Norepinephrine (NE) produced a dose-dependent inhibition of 125I-epidermal growth factor (EGF) binding to adult rat hepatocytes in primary culture. The effect was maximal after 1 hour of incubation with NE and could be blocked by the presence of an alpha 1 -specific adrenergic receptor antagonist. The inhibition of binding correlates with the ability of NE to enhance hepatocyte DNA synthesis in the presence of EGF and appears to be mediated by a reduction of EGF receptor number, without a significant change in receptor affinity. (Copyright (c) 1986 Alan R. Liss, Inc.)