Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Norepinephrine Decreases EGF (Epidermal Growth Factor) Binding in Primary Rat Hepatocyte Cultures.
Author Cruise, J. L. ; Cotecchia, S. ; Michalopoulos, G. ;
CORP Author Duke Univ. Medical Center, Durham, NC. Dept. of Pathology.;Health Effects Research Lab., Research Triangle Park, NC.;National Institutes of Health, Bethesda, MD.
Year Published 1986
Report Number EPA-CR-811687; EPA/600/J-86/455;
Stock Number PB88-185566
Additional Subjects Norepinephrine ; Cells(Biology) ; Rats ; Laboratory animals ; Reprints ; Epidermal growth factor-Urogastrone ; Receptors(Adrenergic) ; DNA ; Phosphoinositides
Library Call Number Additional Info Location Last
NTIS  PB88-185566 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/04/1988
Collation 8p
Norepinephrine (NE) produced a dose-dependent inhibition of 125I-epidermal growth factor (EGF) binding to adult rat hepatocytes in primary culture. The effect was maximal after 1 hour of incubation with NE and could be blocked by the presence of an alpha 1 -specific adrenergic receptor antagonist. The inhibition of binding correlates with the ability of NE to enhance hepatocyte DNA synthesis in the presence of EGF and appears to be mediated by a reduction of EGF receptor number, without a significant change in receptor affinity. (Copyright (c) 1986 Alan R. Liss, Inc.)