||Methods for Analyzing Occupational Cohort Data with Application to Lung Cancer in U.S. Uranium Miners: Techniques for Fitting and Checking Exposure-Time-Response Models.
Halpern, J. ;
Whittemore., A. S. ;
||Stanford Univ., CA. School of Medicine.;National Science Foundation, Washington, DC.;Alfred P. Sloan Foundation, New York.
||NIH-ES-00070 ;CA-23214; EPA/600/J-87/522;
United States ;
Radon compounds ;
Occupational safety and health ;
Cohort studies ;
Uranium mines ;
Radiation-induced neoplasms ;
Lung neoplasms ;
Radiation dose-response relationship ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Two methods were used to examine how lung cancer death rates vary with cumulative exposures to radiation and tobacco among uranium miners. The two methods produced similar results when death rate ratios were taken to be the product of radiation and tobacco effects. The estimates were discrepant when death rate ratios were taken to be the sum of radiation and tobacco effects. Both methods indicated better fit for the multiplicative model. It may be that cumulative exposures are inappropriate measures of the effects of radiation and tobacco on lung cancer death rates, as well as for other pollutants where the assumption of cumulative dose is the basis for risk assessments. (Copyright (c) 1987 Pergamon Journals Ltd.)