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OLS Field Name OLS Field Data
Main Title Role of Metallothionein Induction and Altered Zinc Status in Maternally Mediated Developmental Toxicity: Comparison of the Effects of Urethane and Styrene in Rats.
Author Daston, G. P. ; Overmann, G. J. ; Taubeneck, M. W. ; Lehman-McKeeman, L. D. ; Rogers, J. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. ;Procter and Gamble Co., Cincinnati, OH. Miami Valley Labs. ;California Univ., Davis. Dept. of Nutrition.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/307;
Stock Number PB92-124635
Additional Subjects Teratogenic compounds ; Urethanes ; Styrene ; Metallothionein ; Zinc ; Maternal-fetal exchange ; Rats ; Comparison ; Enzyme induction ; Liver ; Embryo ; Reproduction(Biology) ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-124635 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 02/24/1992
Collation 16p
The authors hypothesize that maternal metallothionein (MT) induction by toxic dosages of chemicals may contribute to or cause developmental toxicity by a chain of events leading to a transient but developmentally adverse decrease in Zn availability to the embryo. The hypothesis was tested by evaluating hepatic MT induction, maternal and embryonic Zn status, and developmental toxicity after exposure to urethane, a developmental toxicant, or styrene, which is not a developmental toxicant. Pregnant Sprague-Dawley rats were given 0 or 1 g/kg urethane ip, or 0 or 300 mg/kg styrene in corn oil po, on Gestation Day 11 (sperm positive = Gestation Day 0). These were maternally toxic dosages. As both treatments decreased food consumption, separate pair-fed control groups were also evaluated for effects on MT and Zn status and development. In addition, Gestation Day 11 rat embryos were exposed to urethane in vitro in order to determine whether urethane has the potential to be directly embryotoxic. Urethane treatment induced hepatic MT 14-fold over control; styrene treatment induced MT 2.5-fold. The MT induction by styrene could be attributed to decreased food intake, as a similar level of induction was observed in a pair-fed untreated control group. However, the level of MT induction by urethane was much greater than that produced by decreased food intake alone. (Copyright (c) 1991 Academic Press, Inc.)