||Induction of Cytochrome P-450-IA1 in Juvenile Fish by Creosote-Contaminated Sediment.
Schoor, W. P. ;
Williams, D. E. ;
Takahashi., N. ;
||Environmental Research Lab., Gulf Breeze, FL. ;Oregon State Univ., Corvallis. Dept. of Food Science and Technology.
Water pollution effects(Animals) ;
Cytochrome P-450 ;
Mixed function oxidases ;
Enzyme induction ;
Liquid chromatography ;
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Intact sediment cores, including their surface layers, were used in simulated field exposure tests of juvenile guppies (Poecilia reticulata) to creosote-contaminated sediments. Mixed-function oxygenase activity was induced in the fish after 43 days of exposure to environmentally realistic, sublethal concentrations of creosote-related compounds. An average 50-fold induction in the cytochrome P-450-IA1 was found in the liver in the absence of any histopathological lesions. The possibility that a threshold level for proliferative liver changes was not reached is discussed in the light of the observed biochemical activation.