| Main Title |
PCBs : cancer dose-response assessment and application to environmental mixtures. |
| Author |
Cogliano, J.
|
| Other Authors |
|
| CORP Author |
Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment. |
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment ; Available from the National Technical Information Service, |
| Year Published |
1996 |
| Report Number |
EPA/600/P-96/001A; NCEA-W-0059; PB96-140603 |
| Stock Number |
PB96-140603 |
| OCLC Number |
34609329 |
| Additional Subjects |
Polychlorinated biphenyls ;
Health effects ;
Dose-response relationships ;
Malignant neoplasms ;
Environmental materials ;
Chemical composition ;
Toxicity ;
Risk assessment ;
Environmental exposure pathway ;
Bioaccumulation ;
Public health ;
Biological effects ;
Laboratory animals ;
Pharmacokinetics ;
Humans
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EIAD |
EPA/600/P-96/001A |
|
Region 2 Library/New York,NY |
11/08/1996 |
| EJDD |
EPA/600/P-96/001A |
|
Env Science Center Library/Ft Meade,MD |
03/14/1997 |
| EJED |
EPA/600/P-96/001A |
|
OCSPP Chemical Library/Washington,DC |
12/12/2003 |
| EKBD |
EPA/600/P-96/001A |
|
Research Triangle Park Library/RTP, NC |
04/26/1996 |
| ELBD ARCHIVE |
EPA 600/P-96/001A |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
DISPERSAL |
| EMBD |
EPA/600/P-96/001A |
|
NRMRL/GWERD Library/Ada,OK |
05/10/1996 |
| ESAD |
EPA 600-P-96-001A |
|
Region 10 Library/Seattle,WA |
12/01/2000 |
| NTIS |
PB96-140603 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
viii, 64 p. ; 28 cm. |
| Abstract |
A cancer dose-response assessment is developed for PCBs, considering toxicity, disposition, and environmental processes to evaluate human cancer risk. Low-dose linear models are applied to animal cancer studies of commercial mixtures to develop a range of potency estimates, then information on environmental processes is used to choose appropriate values for representative classes of environmental mixtures. Guidance is given on applying the assessment to environmental mixtures, different exposure routes, partial lifetime exposure, and mixtures containing dioxin-like compounds. Key to these applications are processes that change PCB mixtures after release into the environment: partitioning, chemical transformation, and preferential bioaccumulation. |
| Notes |
"Written by Dr. Jim Cogliano"--P. viii. "January 1996." "External review draft." "Draft--Do not quote or cite." Includes bibliographical references (p. 48-55). |
