Record Display for the EPA National Library Catalog


Main Title Microinjection of Dynorphin into the Hippocampus Impairs Spatial Learning in Rats.
Author McDaniel, K. L. ; Mundy, W. R. ; Tilson., H. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. Lab. of Molecular and Integrative Neuroscience.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/234;
Stock Number PB91-117044
Additional Subjects Hippocampus ; Learning ; Rats ; Memory ; Histology ; Reprints ; Microinjections ; Dynorphin ; Naloxone ; Dose-response relationships ; Endogenous substances receptors
Library Call Number Additional Info Location Last
NTIS  PB91-117044 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
The effect of hippocampal dynorphin administration on learning and memory was examined in spatial and nonspatial tasks. Bilateral infusion of dynorphin A(1-8)(DYN; 10 or 20 micrograms in one microliter) into the dorsal hippocampus resulted in dose-related impairment of spatial working memory in a radial maze win-stay task. Subsequent experiments found that acquisition of a reference memory task in the water maze was impaired by DYN injections (20 micrograms/microliter) in the dorsal hippocampus, but not in the ventral hippocampus, and that this impairment could be blocked by naloxone. In a nonspatial task, posttraining DYN injections in the dorsal hippocampus had no effect on retention of step-through passive avoidance. These results suggest that dynorphin specifically interferes with spatial learning and memory, and that this effect is mediated by opioid receptors in the dorsal hippocampus.