||Mechanisms of Aldehyde-Induced Bronchial Reactivity: Role of Airway Epithelium.
Leikauf, G. D. ;
||Cincinnati Univ. Medical Center, OH.;Health Effects Inst., Cambridge, MA.
Air pollution effects(Animals) ;
Guinea pigs ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The purpose of the study was to determine whether exposures to environmentally relevant concentrations of two aldehydes of low molecular weight were associated with impaired airway function. Specifically, the study addressed questions of the relative irritant potency of formaldehyde and acrolein on the induction of increased bronchial reactivity to acetylcholine in guinea pigs. The relationship of bronchial reactivity to epithelial damage and inflammation were also examined after both in vivo and in vitro exposures.