This proceeding includes papers presented at the Second U.S./USSR Symposium on Comprehensive Analysis of the Environment. All the papers, except for one, were given in English or Russian at Honolulu, Hawaii, USA between October 23 and October 25, 1975. The paper by Gerasimov, Izrael, and Sokolov was given in New York on October 20, at a joint meeting with Biosphere Reserves Project. The publication of these proceedings is in accordance with the Memorandum of Fourth Meeting of the U.S./USSR Joint Committee on Cooperation in the Field of Environmental Protection, signed in Washington on October 31, 1975, which called for independent publication in both the United States and the Soviet Union. Papers presented were grouped into the following categories: Maximum permissible load; Internal substance cycling in natural ecosystems; Human risk assessment; and Environmental stress and behavior.