| Main Title |
Structure-Activity Relationships for Screening Organic Chemicals for Potential Ecotoxicity Effects. |
| Author |
Veith, G. D. ;
De Foe, D. ;
Knuth, M. ;
|
| CORP Author |
Environmental Research Lab.-Duluth, MN. |
| Year Published |
1985 |
| Report Number |
EPA/600/J-85/224; |
| Stock Number |
PB86-118692 |
| Additional Subjects |
Environmental effects ;
Ecology ;
Toxicity ;
Organic compounds ;
Molecular structure ;
Industrial wastes ;
Esters ;
Assessments ;
Octanol ;
Water ;
Partitions(Mathematics) ;
Fishes ;
Reprints ;
Bioaccumulation ;
Ecological concentration ;
Numerical solution ;
Water pollution effects(Animals)
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-118692 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
The paper presents structure-activity relationships (QSAR) for estimating the bioconcentration factor and acute toxicity of some classes of industrial chemicals using only the n-octanol/water partition coefficient (Log P) which is derived from chemical structure. The bioconcentration factor is estimated by the equation: Log BCF = 0.79 Log P - 0.40 r = 0.93 n = 122. The acute toxicity of polar narcotic chemicals to fathead minnows were substantially greater than non-polar narcotics. Although a comprehensive model is not yet discernable, industrial esters and diesters can be estimated by the equation: Log LC50 = -0.535 Log P - 2.75 r = 0.91 n = 29. Guidelines for selecting tests for ecotoxicity assessments are also presented. |
