Record Display for the EPA National Library Catalog


Main Title Fetotoxic Potential of Municipal Drinking Water in the Mouse.
Author Chernoff, Neil ; Rogers, Ellen ; Carver, Brenda ; Kavlock, Robert ; Gray, Earl ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Year Published 1978
Report Number EPA/600/J-79/037;
Stock Number PB80-124456
Additional Subjects Potable water ; Diets ; Laboratory animals ; Mice ; Reprints ; Congenital abnormalities ; Drinking water ; Durham(North Carolina) ; Fetuses ; Teratogenesis
Library Call Number Additional Info Location Last
NTIS  PB80-124456 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
Mice (CD-1 strain) were placed on diets containing either municipal drinking water (Durham, North Carolina) or water that had been distilled and passed through cartridges to reduce organics and remove inorganics. After a two-week acclimation period, animals were bred and pregnancy confirmed by the presence of a sperm plug. During the 8-month course of the study, approximately 500 pregnant mice were sacrificed on day 18 of gestation and their fetuses examined for visceral and skeletal anomalies. No significant water-related effects were found on any fetal parameter studied except for a 28.1 percent incidence of supernumerary ribs in the tap-water group as compared to 21.1 percent in the purified-water group. No differences were noted in the type or occurrence of anomalies between the two groups. A month to month variation was observed in a number of parameters. The degree of variation was similar for the treatment groups, suggesting that these changes might be random fluctuations.