Record Display for the EPA National Library Catalog


Main Title Drug repositioning : bringing new life to shelved assets and existing drugs /
Other Authors
Author Title of a Work
Barratt, Michael J.
Frail, Donald.
Publisher John Wiley & Sons,
Year Published 2012
OCLC Number 758943206
ISBN 9780470878279 (cloth); 0470878274 (cloth)
Subjects Drug development ; Pharmaceutical industry ; Drug Repositioning ; Computational Biology--methods ; Drug Industry--economics ; Pharmaceutical Preparations--economics
Library Call Number Additional Info Location Last
ELBM  RM301.25.D78 2012 AWBERC Library/Cincinnati,OH 11/19/2012
Collation xx, 477 p. : ill. ; 24 cm.
Includes bibliographical references and index.
Contents Notes
Drug repositioning : the business case and current strategies to repurpose shelved candidates and marketed drugs / John Arrowsmith and Richard Harrison -- Opportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs / Donald E. Frail and Michael J. Barratt -- Clinical and operational considerations in repositioning marketed drugs and drug candidates / Damian O'Connell, David J. Sequeira, and Maria L.Miller -- Regulatory considerations and strategies for drug repositioning / Ken Phelps -- Computational and bioinformatic strategies for drug repositioning / Richard Mazzarella and Craig Webb -- Mining scientific and clinical databases to identify novel uses for existing drugs / Christos Andronis ... [et al.] -- Predicting the polypharmacology of drugs : identifying new uses through chemoinformatics, structural informatics, and molecular modeling-based approaches / Li Xie ... [et al.] -- Systematic phenotypic screening for novel synergistic combinations: a new paradigm for repositioning existing drugs / Margaret S. Lee -- Phenotypic in vivo screening to identify new, unpredicted indications for existing drugs and drug candidates / Michael S. Saporito, Christopher A. Lipinski, and Andrew G. Reaume -- Old drugs yield new discoveries : examples from the prodrug, chiral switch and site-selective deuteration strategies / Adam J. Morgan ... [et al.] -- Repurposing drugs for tropical diseases : case studies and open-source screening initiatives / Curtis R. Chong -- Drug repositioning efforts by nonprofit foundations -- Business development strategies in the repositioning industry / Aris Persidis and Elizabeth T. Stark -- A case study in drug repositioning : Sosei / Akinori Mochizuki and Makiko Aoyama.