| Main Title |
Evidence That Drug-Resistant Alloreactive T Cells May Contribute to Human Graft Rejection. |
| Author |
Stanford, W. L. ;
Strauss, G. H. S. ;
Finn., O. J. ;
|
| CORP Author |
Duke Univ., Durham, NC.;National Institutes of Health, Bethesda, MD.;Environmental Protection Agency, Washington, DC. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
PO1-AI19368; EPA/600/J-90/175; |
| Stock Number |
PB91-115774 |
| Additional Subjects |
Humans ;
Reprints ;
T lymphocytes ;
Homologous transplantation ;
Graft rejection ;
Immunosuppressive agents ;
Drug resistance ;
Azathioprine ;
Autoradiography
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-115774 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
6p |
| Abstract |
The objective of the study was to determine whether resistance to immunosuppressive drugs by transplant recipient's T cells could contribute to continued graft rejection, in spite of immunosuppressive therapy. The T cell lines used in the series of experiments were originally established from T cells that had infiltrated kidney or liver grafts and initiated rejections in patients receiving immunosuppressive drugs, including the purine analogue azathioprine (AZ). The authors have used a proliferation assay and the Strauss-Albertini test to analyze the T cell lines. Both assays use 6-thioguanine (6-TG), an amino derivative of AZ, as the selective agent to measure the resistance to AZ. (Copyright (c) 1990 by Williams and Wilkins.) |
