Record Display for the EPA National Library Catalog
RECORD NUMBER: 21 OF 21
|OLS Field Name||OLS Field Data|
|Main Title||Teratologic Evaluation of Inhaled Methyl Ethyl Ketone in Rats, prepared by Dow Chemical Company with Cover Letter.|
|CORP Author||Texaco, Inc., Beacon, NY.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Publisher||1 Dec 1982|
|Additional Subjects||Methyl ethyl ketone ; Toxicology ; Evaluation ; Toxicity ; Solvents ; Rats ; Pregnancy ; Inhalation ; Gestation ; Water consumption ; Incidence ; Exposure ; Laboratory tests ; Dow Chemical Company|
Pregnant Sprague-Dawley rats were exposed to 0, 400, 1000 or 3,000 ppm methyl ethyl ketone (MEK) on day 6 through 15 of gestation. Maternal toxicity, as evidenced by decreased weight gain and increased water consumption, was observed among rats exposed to 3,000 ppm MEK. Slight fetotoxicity was observed as evidenced by an increased incidence of some minor skeletal variants among litters from animals exposed to 3,000 ppm MEK. No embryotoxic effects were observed. Although a slight fetotoxic effect and slight maternal toxicity were observed at the highest exposure level, MEK was not embryo-toxic or teratogenic in rats at exposure levels up to 3,000 ppm.