| Main Title |
Microinjection of Dynorphin into the Hippocampus Impairs Spatial Learning in Rats. |
| Author |
McDaniel, K. L. ;
Mundy, W. R. ;
Tilson., H. A. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. Lab. of Molecular and Integrative Neuroscience. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/234; |
| Stock Number |
PB91-117044 |
| Additional Subjects |
Hippocampus ;
Learning ;
Rats ;
Memory ;
Histology ;
Reprints ;
Microinjections ;
Dynorphin ;
Naloxone ;
Dose-response relationships ;
Endogenous substances receptors
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-117044 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
The effect of hippocampal dynorphin administration on learning and memory was examined in spatial and nonspatial tasks. Bilateral infusion of dynorphin A(1-8)(DYN; 10 or 20 micrograms in one microliter) into the dorsal hippocampus resulted in dose-related impairment of spatial working memory in a radial maze win-stay task. Subsequent experiments found that acquisition of a reference memory task in the water maze was impaired by DYN injections (20 micrograms/microliter) in the dorsal hippocampus, but not in the ventral hippocampus, and that this impairment could be blocked by naloxone. In a nonspatial task, posttraining DYN injections in the dorsal hippocampus had no effect on retention of step-through passive avoidance. These results suggest that dynorphin specifically interferes with spatial learning and memory, and that this effect is mediated by opioid receptors in the dorsal hippocampus. |
