| Main Title |
Evaluation of the potential carcinogenicity of BIS(Chloromethyl)ether (542-88-1) : in support of reportable quantity adjustments pursuant to CERCLA Section 102 / |
| CORP Author |
Syracuse Research Corp., NY. ;Environmental Monitoring and Services, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. |
| Publisher |
United States. Environmental Protection Agency, |
| Year Published |
1988 |
| Report Number |
EPA 600/8-91/083; EPA-68-03-3112; EPA-68-03-3182; OHEA-C-073-044; PB93185080 |
| Stock Number |
PB93-185080 |
| OCLC Number |
41674690 |
| Subjects |
Carcinogenicity testing ;
Carcinogens ;
Dichloromethyl ether--Toxicity ;
Chloromethyl methyl ether--Toxicity ;
Risk assessment
|
| Additional Subjects |
Carcinogens ;
Toxicity ;
Bis(chloromethyl)ether ;
Risk assessment ;
Carcinogenicity tests ;
Humans ;
Animals ;
Dose-response relationships ;
CAS 542-88-1
|
| Internet Access |
|
| Local Library Info |
| Library |
Local Subject |
Local Note |
| EJE |
BIS(chloromethyl)ether--Toxicity ; CAS no. 542-88-1 |
|
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJED |
EPA 600/8-91/083 |
|
OCSPP Chemical Library/Washington,DC |
07/16/1999 |
| NTIS |
PB93-185080 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1 v. (various pagings) ; 28 cm. |
| Abstract |
Bis(chloromethyl)ether is a human carcinogen, classified as weight-of-evidence Group A under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on potential carcinogenicity from animal studies is 'Sufficient', and the evidence from human studies is 'Sufficient'. The potency factor (F) for bis(chloromethyl)ether is estimated to be 10,377/(mg/kg/day), placing it in potency group 1 according to the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986b). Combining the weight-of-evidence group and the potency group, bis(chloromethyl)ether is assigned a 'HIGH' hazard ranking for the purposes of RQ adjustment. |
| Notes |
"June 1988. Final." |
