Record Display for the EPA National Library Catalog


Main Title Principles for modelling dose-response for the risk assessment of chemicals /
Publisher World Health Organization,
Year Published 2009
OCLC Number 264018462
ISBN 9789241572392; 9241572396
Subjects Drugs--Dose-response relationship ; Risk assessment ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; Risk Assessment--methods ; Environmental Exposure--prevention & control ; Models, Theoretical
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
ELBM  RA565.A1.E63 2009 no.239 AWBERC Library/Cincinnati,OH 08/20/2019
Collation xx, 137 pages : illustrations
"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals." Includes bibliographical references (pages 103-110).
Contents Notes
Summary, conclusions, and recommendations -- Introduction -- Risk analysis -- Dose-response modelling : basic concepts -- Dose-response modelling : why and when to use it -- Principles of dose-response modelling -- Communicating the results of dose-response modelling -- Conclusions and recommendations. This volume is part of the ongoing review of the underlying scientific bases for decision-making in chemical risk assessment by International Program on Chemical Safety. It involves specific consideration of the area of dose-response assessment in the evaluation of information from toxicological studies in animals and from human clinical and epidemiological studies. It covers toxicants with threshold effects and those for which there may be no practical threshold, such as substances that are genotoxic and carcinogenic. The discussions are concerned with that subset of cause-effect relationships commonly referred to as dose-response models, which are typically used to characterize the biological effects of intentional (e.g. drugs and nutrients) and unintentional (e.g. contaminants) exposure to chemicals. This report is intended primarily to provide descriptive guidance for risk assessors in using dose-response modeling in hazard characterization. It will also provide mathematical modelers with an appreciation of issues to be considered when modeling in the context of the risk assessment process. Risk managers will be able to obtain a general understanding of the applications and limitations of dose-response modeling. For both risk assessors and risk managers, some considerations for communicating the results of risk assessments that use dose-response modeling are presented.--Publisher's description.