Record Display for the EPA National Library Catalog

RECORD NUMBER: 563 OF 1115

Main Title Initial Submission: Letter to USEPA re: Results of Two-Week Preliminary Oral Toxicity Study with S-1955 (Confidential Information), an Experiment Insecticide and Miticide, in Dogs, dated 11/09/99 (Sanitized).
CORP Author ;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 12 Nov 1999
Year Published 1999
Report Number 8EHQ-1199-14589S;
Stock Number OTS-0559836
Additional Subjects Insecticides ; Miticides ; Toxicity ; Oral toxicity ; Dogs ; Laboratory animals ; Dosage ; Convulsions ; Mortality ; S-1955
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS-0559836 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Abstract
The company has recently completed a two week preliminary oral toxicity study with dogs. S-1955 (experimental insecticide and miticide) was administered daily by oral capsule to beagle dogs (two/sex/group) at doses of 0 (control), 10, 30, and 100 mg/kg/day for two weeks. Two males and one female in the highest dose group showed signs of convulsions. One female and one male died on day 14. In addition, tremor, salivation and/or hypoactivity were observed in other animals receiving this dose level. For those animals receiving 30 mg/kg/day, slight decreases in food consumption were observed, but no neurotoxic signs were observed. Histopathological examinations have not yet been performed on the animals.