Record Display for the EPA National Library Catalog


Main Title 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Damage of Striatal Dopaminergic Fibers Attenuates Subsequent Astrocyte Response to MPTP.
Author O'Callaghan, J. P. ; Miller, D. B. ; Reinhard, J. F. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Wellcome Research Labs., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/283;
Stock Number PB91-145045
Additional Subjects Toxicity ; Corpus striatum ; Dopamine receptors ; Astrocytes ; Glial fibrillary acidic protein ; Tyrosine hydroxylase ; Nerve cells ; Mice ; Dose-response relationships ; Reprints ; Methyl phenyl tetrahydropyridine
Library Call Number Additional Info Location Last
NTIS  PB91-145045 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Acute administration of the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to the C57B1/6 mouse caused a rapid decrease in the amount of striatal tyrosine hydroxylase (TH), a marker of dopaminergic neurons, followed by a large increase in the astrocyte protein, glial fibrillary acidic protein (GFAP). The astrocyte (GFAP) response declined to baseline 3 weeks after administration of MPTP. Administration of a second dosage of MPTP at this time evoked a second GFAP response. The magnitude of the second response, however, was decreased in comparison to the response seen after only a single exposure to MPTP. Increasing the initial dosage of MPTP resulted in greater reductions of the second GFAP response. These data indicate that damage to striatal dopaminergic neurons reduces the signal available for initiating a second astrocyte response to MPTP.