Record Display for the EPA National Library CatalogRECORD NUMBER: 6 OF 17
|Main Title||Comparison of the D1-Dopamine Agonists SKF-38393 and A-68930 in Neonatal 6-Hydroxydopamine-Lesioned Rats: Behavioral Effects and Industion of c-fos-Like Immunoreactivity.|
|Author||Johnson, K. B. ; Criwell, H. E. ; Jensen, K. F. ; Simson, P. E. ; Mueller, R. A. ;|
|CORP Author||North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.|
|Additional Subjects||Dopamine receptors ; Proto-oncogene proteins c-fos ; Pharmacology ; Oxidopamine ; Comparison ; Locomotion ; Rats ; Corpus striatum ; Immunohistochemistry ; Animal behavior ; Reprints ; SKF-38393 ; A-68930|
Administration of the selective D1-dopamine receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SKF-38393) to neonatal 6-hydroxydopamine-lesioned rats results in profound behavioral manifestations and induction of striatal c-fos-like immunoreactivity. The full D1-dopamine agonist l,(R,S)1-aminomethyl-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran hydrochloride (A-68930), like SKF-38393, produced a dose-dependent, D1-selective increase in locomotor activity and striatal c-fos-like immunoreactivity. These results with A-68930 provide additional evidence that the specific behavioral and biochemical responses observed in neonatally lesioned rats after SKF-38393 administration are due to actions on D1-dopamine receptors, and indicate that A-68930 provides a new tool for investigating D1-dopamine receptor function.