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Main Title Comparison of the D1-Dopamine Agonists SKF-38393 and A-68930 in Neonatal 6-Hydroxydopamine-Lesioned Rats: Behavioral Effects and Industion of c-fos-Like Immunoreactivity.
Author Johnson, K. B. ; Criwell, H. E. ; Jensen, K. F. ; Simson, P. E. ; Mueller, R. A. ;
CORP Author North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/375;
Stock Number PB93-107209
Additional Subjects Dopamine receptors ; Proto-oncogene proteins c-fos ; Pharmacology ; Oxidopamine ; Comparison ; Locomotion ; Rats ; Corpus striatum ; Immunohistochemistry ; Animal behavior ; Reprints ; SKF-38393 ; A-68930
Library Call Number Additional Info Location Last
NTIS  PB93-107209 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Administration of the selective D1-dopamine receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SKF-38393) to neonatal 6-hydroxydopamine-lesioned rats results in profound behavioral manifestations and induction of striatal c-fos-like immunoreactivity. The full D1-dopamine agonist l,(R,S)1-aminomethyl-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran hydrochloride (A-68930), like SKF-38393, produced a dose-dependent, D1-selective increase in locomotor activity and striatal c-fos-like immunoreactivity. These results with A-68930 provide additional evidence that the specific behavioral and biochemical responses observed in neonatally lesioned rats after SKF-38393 administration are due to actions on D1-dopamine receptors, and indicate that A-68930 provides a new tool for investigating D1-dopamine receptor function.