||Age-Related Alterations in the Stimulated Release In vitro of Catecholamines and Luteinizing Hormone-Releasing Hormone from the Male Rat Hypothalamus.
Goldman, J. M. ;
Cooper, R. L. ;
Rehnberg, G. L. ;
Gabel, S. ;
McElroy, W. K. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.;Iowa Univ., Iowa City. Coll. of Medicine.
LH-FSH releasing hormone ;
Tissue culture ;
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Using an in vitro perifusion system, the present study investigated the possibility that alterations in catecholamine and luteinizing hormone-releasing hormone (LHRH) secretion from the male rat mediobasal hypothalamus are present during the period of middle-age. The results indicate that, while tissue concentrations and baseline secretion of norepinephrine, dopamine and LHRH were similar between age groups, the patterns of dopamine and LHRH release in response to a series of depolarizing stimuli was different in the older animals. After all challenges, dopamine concentrations in the perifusate declined much more sharply for the middle-aged group, a finding that may be associated with a decrease with age in the pool of transmitter available for ready release. (Copyright (c) 1987 Plenum Publishing Corporation.)