||Hyperactivity and Hypoactivity Produced by Lesions to the Mesolimbic Dopamine System.
Koob, George F. ;
Stinus, Luis ;
Moal, Michel Le ;
||Salk Inst., San Diego, CA. Arthur Vining Davis Center for Behavioral Neurobiology.;Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
Radio frequencies ;
Locomotor activity ;
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Spontaneous locomotor activity and the locomotor response to amphetamine and apomorphine were studied in rats subjected to either radiofrequency(RF), 6-hydroxydopamine (6-OHDA) of both RF and 6-OHDA lesions of the mesolimbic dopamine (DA) system. Large 6-OHDA lesions of the ventral tegmental area (VTA) or of the nucleus accumbens (N.Acc) produced hypo-activity in the open field, a complete blockade of the locomotor stimulating effects of D-amphetamine, and a profound supersensitive response to apomorphine as measured by a significant increase in locomotor activity as compared to sham-operated animals.