||Effects of Postnatal Trimethyltin or Triethyltin Treatment of CNS Catecholamine, GABA (Gamma-Aminobutyric Acid), and Acetylcholine Systems in the Rat.
Mailman, R. B. ;
Krigman, M. R. ;
Frye, G. D. ;
Hanin, I. ;
||North Carolina Univ. at Chapel Hill. School of Medicine. ;Pittsburgh Univ., PA. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Ammino compounds ;
Butyric acid ;
Trimethyltin sulfate ;
Trimethyltin hydroxide ;
||Some EPA libraries have a fiche copy filed under the call number shown.
The effects on brain neurochemistry of two neurotoxic tin compounds, trimethyltin (TMT) hydroxide and triethyltin (TET) sulfate, were examined. Long-Evans rats were treated with TMT hydroxide (1 mg/kg, i.p.) on alternate days from day 2 to 29 of life. These treatments caused a weight deficit of 10-20% by the time the animals were killed on day 55 by head-focused microwave irradiation. These TMT treatments are known to cause severe neuronal loss in the hippocampus and lesser damage in other brain regions. (Copyright (c) 1983 International Society for Neurochemistry.)