Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Evaluation of Dowanol Pm in the Rat Hepatocyte Unscheduled DNA Synthesis Assay.
CORP Author Dow Chemical Co., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 2000
Report Number 86-890001234
Stock Number OTS0520744
Additional Subjects Toxicology ; Health effects ; 1-methoxy-2-propanol (107-98-2) ; Genotoxicity ; DNA Effects ; Mammals ; Rats ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 107-98-2
Library Call Number Additional Info Location Last
NTIS  OTS0520744 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 14p
Genotoxicity of 1-methoxy- 2-propanol was evaluated in the rat hepatocyte primary culture/DNA repair assay. The compound was tested at concentrations of 3.16x10E-5, 1x10E-4, 3.16x10E-4, 1x10E-3, 3.16x10E-3, 1x10E-2, 3.16x10E-2, and 1x10E-1 M, in Williams Medium E with 10% fetal calf serum. The negative control and positive control groups were cell cultures exposed to the media only, or the media plus 2- acetylaminofluorene (1x10E-7, 1x10E-6, or 1x10E-5 M) in 1% DMSO, respectively. The treatment was cytotoxic to the cell cultures at 3.16x10E-2 and 1x10E-1 M. The treatment had no effect on the rate of DNA repair, indicating a lack of genotoxicity of 1-methoxy-2- propanol in this cell culture assay.