| Main Title |
Scientific basis for the development of the international toxicity equivalency factor (I-TEF) method of risk assessment for complex mixtures of dioxins and related compounds / |
| Author |
Safe, S. H. ;
Kutz, F. W. ;
Bottimore, D. P.
|
| CORP Author |
NATO Committee on the Challenges of Modern Society, Brussels (Belgium). ;Texas A and M Univ., College Station. ;Versar, Inc., Springfield, VA.;Environmental Protection Agency, Washington, DC. |
| Publisher |
Committee on the Challenges of Modern Society, |
| Year Published |
1988 |
| Report Number |
68-02-4254; EPA 600-6-90-015; NATO/CCMS-178; EPA-68-02-4245; 600-R-88-104; PB91-109991 |
| Stock Number |
PB91-109991 |
| OCLC Number |
22469929 |
| Subjects |
Dioxins ;
Dioxins--Research ;
Dioxins--Law and legislation
|
| Additional Subjects |
Dioxins ;
Toxicity ;
Pollution ;
Bioassay ;
Risk assessment ;
Environmental impacts ;
Dosage ;
Response ;
Rats ;
Fly ash ;
Pyrolysis ;
Municipalities ;
Concentration(Composition) ;
Exposure ;
Humans ;
EC50 ;
Polychlorinated dibenzo p-dioxins ;
Dibenzofurans
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EHAM |
EPA 600-6-90-015 |
|
Region 1 Library/Boston,MA |
05/25/2016 |
| ELBD ARCHIVE |
EPA-600-R-88-104 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ESAD |
PB91-109991 |
|
Region 10 Library/Seattle,WA |
01/27/2006 |
| NTIS |
PB91-109991 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
iii, 56 pages. |
| Abstract |
The Pilot Study on International Information Exchange on Dioxins and Related Compounds was initiated to apply the cooperative efforts of several nations to address issues assoc. with PCDDs, PCDFs, and related compounds. The three-year study was conducted under the aegis of the CCMS of NATO. The report presents a detailed discussion of the scientific basis for the development of toxicity equivalency factors and provides the toxicity data and methodology used to determine the I-TEFs. Section 2 discusses background information on PCDDs and PCDFs. Section 3 discusses the need for I-TEFs. Section 4 presents the mechanisms of toxicity of these compounds. Section 5 provides a discussion of the development of TEFs from experimental toxicity data. |
| Notes |
Cover title. "Report of the NATO/CCMS Pilot Study on International Information Exchange on Dioxins and Related Compounds"--Page [i]. "December 1988"--Cover. "Contract No. 68-02-4254"--Page [i]. Includes bibliographical references (pages 46-56). |
