Record Display for the EPA National Library Catalog


Main Title Subacute Intubation Study on Rats with the Compound 2,3,7,8-Tetrachloridioxin.
Author King, Maurice E. ; Roesler., Alfred R. ;
CORP Author IIT Research Inst., Chicago, Ill. Life Sciences Div.;Environmental Protection Agency, Washington, D.C.
Year Published 1974
Report Number IITRI-L6073-12; EPA/68-01-2224; IITRI-L6073;
Stock Number PB-257 677
Additional Subjects Herbicides ; Toxicity ; Toxicology ; Contaminants ; Rats ; Bioassay ; Dosage ; Dose rate ; Body weight ; Histology ; Pathology ; Sublethal dosage ; Liver ; Oxygen heterocyclic compounds ; Chlorine organic compounds ; Dioxin/tetrachlorodibenzo ; T 2-4-5 herbicide
Library Call Number Additional Info Location Last
NTIS  PB-257 677 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 60p
The report describes a 12-month study to determine the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, (TCDD), an extremely toxic contaminant of the herbicide 2,4,5-T. Male and female rats were intubated twice weekly to provide 0, 0.1 or 1.0 ug/kg/wk of TCDD dissolved in acetone diluted with corn oil. The animals were treated for a total of 28 weeks and held for an additional 12-week recovery period. Body weight observations were made weekly throughout the entire test period. Groups of rats were killed at the end of 2, 4, 8, 16 and 28 weeks of treatment and after 4 and 12 weeks recovery. TCDD was observed to be toxic but not lethal to rats. The extent of the toxic effects, which were manifested by centrilobular fatty change and increased hepatocellular turnover, were confined to the liver and were more severe in male than in female rats.