| Contents Notes |
1,4-Dioxane is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1984). Evidence on potential carcinogenicity from animal studies is "Sufficient," and the evidence from human studies is "Inadequate." The potency factor (F) for 1,4-dioxane is estimated to be 0.034 (mg/kg/day)p-1s, placing it in potency group 3 according to the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986). Combining the weight of evidence group and the potency group, 1,4-dioxane is assigned a "LOW" hazard ranking for the purpose of RQ adjustment. |
