| Main Title |
Age-Related Percutaneous Penetration of 2-sec-Butyl-4-6-Dinitrophenol (Dinoseb) in Rats. |
| Author |
Hall, L. L. ;
Fisher, H. L. ;
Sumler, M. R. ;
Hughes, M. F. ;
Shah, P. V. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. ;Hoffmann-La Roche, Inc., Nutley, NJ. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-92/309; |
| Stock Number |
PB92-227495 |
| Additional Subjects |
Pesticides ;
Aging(Biology) ;
Skin absorption ;
Toxicity ;
Rats ;
In vivo analysis ;
In vitro analysis ;
Tables(Data) ;
Body weight ;
Organ weight ;
Feces ;
Urine ;
Pharmacokinetics ;
Reprints ;
Dinoseb
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-227495 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
12p |
| Abstract |
The effect of age, dose, and method of dermal penetration assessment on the percutaneous penetration of C14-dinoseb have been determined in the Fischer rat. Dermal absorption was shown to be dependent on age and independent of dose. In vitro measurement of dermal absorption was found to produce results quantitatively similar to in vivo results, but the method was not sensitive enough to detect small differences in skin absorption. Through the use of a physiological compartmental model, kinetic differences in the disposition of dinoseb in young and adult rats were identified and quantitated. The study was initiated by a request from OTS/OPP. |
