Record Display for the EPA National Library Catalog


Main Title Carcinoma of the Exocrine Pancreas in Medaka.
Author Fournie, J. W. ; Hawkins, W. E. ; Battalora, M. S. J. ; Walker., W. W. ;
CORP Author Environmental Research Lab., Gulf Breeze, FL. ;Gulf Coast Research Lab., Ocean Springs, MS.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/341;
Stock Number PB92-129782
Additional Subjects Water pollution effects(Animals) ; Carcinogens ; Oryzias ; Pancreatic neoplasms ; Benzopyrenes ; Methylazoxymethanol acetate ; Carcinogenicity tests ; Histology ; Peritoneal neoplasms ; Reprints ; Dimethylbenzanthracenes
Library Call Number Additional Info Location Last
NTIS  PB92-129782 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Eight cases of acinar cell carcinoma of the exocrine pancreas were diagnosed in Japanese medaka (Oryzias latipes) from a pool of approximately 10,000 specimens used in a variety of carcinogenesis bioassays. Three cases occurred in specimens from control groups and one case in a specimen exposed to benzo(e)pyrene (BeP), a noncarcinogenic isomer of benzo(a)pyrene (BaP). Four cases occurred in specimens exposed to known carcinogens including two cases in specimens exposed to 7,12-dimethylbenz(a)anthracene (DMBA), one in a medaka exposed to benzo(a)pyrene, and one in a specimen exposed to methylazoxymethanol acetate (MAM-Ac). Pancreatic carcinoma was probably the cause of death in five cases. The neoplasms appeared to originate in the mesentery near the abdominal surface of the liver.