Record Display for the EPA National Library Catalog

RECORD NUMBER: 6 OF 7

OLS Field Name OLS Field Data
Main Title Repeated-Dose (28-Day) Dermal Toxicity Study with Dimethyl Disulfide (DMDS) in Rabbits with Cover Letter dated 04/18/90.
CORP Author Elf Atochem North America, Philadelphia, PA.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 24 Apr 1990
Year Published 1990
Report Number FYI-OTS-0490-0696;
Stock Number OTS-0000696-1
Additional Subjects Rabbits ; Toxicity ; Central nervous system ; Behavior ; Dimethyl disulfide ; Dermal toxicity ; Albino rabbits ; Dermal occlusive application ; Sham-treated
Holdings
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Status
NTIS  OTS-0000696-1 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 10/08/2007
Collation 333p
Abstract
The toxicity of DMDS was examined in a repeated-dose (28-day) dermal toxicity study with four groups of albino rabbits, the control and top-dose group consisting of 10 males and 10 females, and the low- and mid-dose group consisting of 5 males and 5 females. The test substance was administered daily, by dermal occlusive application. The control group was sham-treated with the occlusive dressing only. The animals of the low- and mid-dose group were treated five days a week during a four-week period, whereas animals of the top-dose group were treated with the test substance for 2 12 weeks (i.e. 13 days of treatment). The dose levels applied were 0.01, 0.1, and 1.0 ml DMDS/kg body weight/day, which is equivalent to 10.63, 106.3, and 1063 mg DMDS/kg body weight/day, respectively, and the daily exposure period was 6 hours. The study was started on April 24, 1989 and terminated on May 23, 1989.