| Main Title |
Dermal Absorption of Pesticides Calculated by Deconvolution. |
| Author |
Fisher, H. L. ;
Most, B. ;
Hall, L. L. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC. |
| Year Published |
1985 |
| Report Number |
EPA/600/J-85/194; |
| Stock Number |
PB86-120342 |
| Additional Subjects |
Pesticides ;
Dermatology ;
Toxicology ;
Absorption ;
Herbicides ;
Urine ;
Blood analysis ;
Isotopic labeling ;
Reprints ;
Environmental health ;
Deconvolution
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-120342 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
16p |
| Abstract |
Using published human data on skin-to-urine and blood-to-urine transfer of 12 pesticides and herbicides, the skin-to-blood transfer rates for each compound were estimated by two numerical deconvolution techniques. Regular constrained deconvolution produced an estimated upper limit on cumulative dermal absorption of the radiolabel, while minimized deconvolution produced an upper bound on cumulative dermal absorption of parent compound. Dermal absorption rate was largest within 8 h of dosing for all pesticides examined. The deconvolution technique described here permits the calculation of the temporal aspect of dermal absorption for linear systems. |
