| Main Title |
Initial Submission: Skin Sensitization Test in Guinea Pigs (Maximization Method of Magnusson, B. and Kligman, A.M.) of Dibenzyl Disulfide, with Cover Letter dated 12/18/1995. |
| CORP Author |
Elf Atochem North America, Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1996 |
| Report Number |
8EHQ-0196-13572 |
| Stock Number |
OTS0558446 |
| Additional Subjects |
Toxicology ;
Health effects ;
Toxic substances ;
Dibenzyl disulfide ;
Laboratory animals ;
Primary dermal sensitization ;
Mammals ;
Guinea pigs ;
Dermal ;
CAS No 150-60-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0558446 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
34p |
| Abstract |
Thirty guinea-pigs were allocated to two groups: a control group 1 (five males and five females) and a treated group 2 (ten males and ten females). On day 1, in the dorsal region between the shoulders, intradermal injections of Freund's complete adjuvant mixed with the test substance (treated group) or the vehicle (control group) were prepared. On day 7, the same region received a topical application of sodium laurylsulfate in vaseline (10% w/w) in order to induce local irritation. On day 8, this same test site was treated by topical application of the test substance (treated group) or the vehicle (control group) and was covered by an occlusive dressing for 48 hours. Test substance and vehicle were maintained under an occlusive dressing for 24 hours. Skin reactions were evaluated approximately 24 and 48 hours later. |
