||Industrial Bio-Test Labs., Inc., Northbrook, IL.; Rhone-Poulenc Ag Co., Research Triangle Park, NC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
The test material was extremely irritating in the dermal toxicity study. Well defined erythema, severe edema, subdermal hemorrhages, and second and third degree burns were observed at 24 hours. By Day 14, necrosis, eschar, fissuring and wrinkling were observed. The dermal LD50 was between 267 and 400 mg/kg. In the oral toxicity study, antemortem signs included ataxia, salivation, muscular weakness, and convulsions. Hypoactivity was observed at lethal and nonlethal doses. The oral LD50 was 966 mg/kg. Severe, irreversible irritation was observed in the eye and skin irritation studies. Chemical burns and hemorrhages were seen one hour after instillation of the test material in rabbits' eyes. Eye irritation increased in severity throughout the 14 day observation period. In the dermal study, third degree chemical burns and subdermal hemorrhages were recorded at 24 and 72 hours.