| Main Title |
Toxicology of Ethylene Oxide Derivatives: the Skin Sensitizing Potential of Heptanal (Final Report) with Attachment and Cover Letter Dated 12/02/1991. |
| CORP Author |
Shell Oil Co., Houston, TX.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1991 |
| Report Number |
86-920000444 |
| Stock Number |
OTS0534500 |
| Additional Subjects |
Toxicology ;
Health effects ;
Heptanal (111-71-7) ;
Primary Dermal Sensitization ;
Mammals ;
Guinea Pigs ;
Dermal ;
Toxic substances ;
Laboratory animals ;
CAS No 111-71-7
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0534500 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
17p |
| Abstract |
Heptanal (CAS No. 111-71-7) was evaluated for dermal sensitization in the guinea-pig maximization test of Magnusson and Kligman. The test substance was applied at a dosage of 0.1 ml to the shoulder region of 10 male and 10 female guinea pigs ('P' strain). One test animal died before induction and another was sacrificed because it had lost 27% of its initial body weight. Therefore, only 18 rabbits were included in the challenge procedure. Two weeks after induction, a challenge patch of 0.1 ml of test substance was applied at a previously untreated site under occlusive wrap. Results of the challenge procedure include 4 animals that showed a positive response after 24-hours and 3 animals that showed positive responses after 48 hours. |
