Dermal irritancy and corrosivity of di-amylamine (CAS No. 2050-92-2) was evaluated in 6 New Zealand White rabbits each administered three 0.5 mL dermal applications upon intact skin at 3 distinct sites. The semi-occlusive bindings covering the 3 applications were removed and the skin cleansed of any residual test article at 3-minute, 1-hour, and 2-hour intervals, respectively. Signs of irritation or corrosion were assessed immediately and at 1 hour following removal of the patches according to the Dermal Grading System for Potential In-Depth Injury at the 3-minute sites and by the method of Draize at the 1- and 2-hour sites. Upon a 1-hour assessment after removal of the 2-hour application, humane euthanasia of all treated animals due to excessive dermal irritation terminated study. Nearly all test sites for all exposure periods exhibited slight to moderate blanching initially. The 3-minute exposure also produced slight necrosis at 1 site that was more severe and prevalent with increasing periods of exposure. Both 1-hour and 2-hour applications were also characterized by severe erythema and slight-moderate edema. One hour following removal of patches, grade 1-4 necrosis was noted on all sites of 3-minute or 1-hour exposures, while grade 1-3 eschar and severe edema was found on all 2- hour exposure sites. Superficial lightening and erythema extending beyond the test site were also noted in both 1- and 2-hour sites, while ulceration beyond the test site characterized 2-hour sites only 1 hour after patch removal. Researchers concluded that di-amylamine is corrosive to rabbit skin at 3- minute, 1-hour and 2-hour long exposures.