Record Display for the EPA National Library Catalog
RECORD NUMBER: 135 OF 308| Main Title | Initial Submission: Skin Tests on Guinea Pigs of N,N'-Di-Sec-Butyl-P-Phenyldiamine and Four Other Chemicals with Cover Letter dated 10/15/1992. | |||||||||||
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| CORP Author | Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 1992 | |||||||||||
| Report Number | 8EHQ-1092-11539 | |||||||||||
| Stock Number | OTS0571469 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; Primary dermal irritation ; Mammals ; Guinea pigs ; Dermal ; Primary dermal sensitization ; CAS No 101-96-2 ; CAS No 3081-14-9 ; CAS No 4351-01-8 ; CAS No 104093-14-3 | |||||||||||
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| Collation | 15p | |||||||||||
| Abstract | After determining the peroral toxicity of Silicone L-77 by single dose in male and female rats and finding it to be moderate to slight, the 90-day feeding studies were undertaken. The material was incorporated in the diet of Harlan-Wistar albino rats for three months to produce nominal dosage levels of 1.0, 0.5, 0.33, 0.11 and 0.00 gm./kg. The following criteria of effect were examined: mortality; appetite; liver and kidney weights; gross and micropathology; and mean body weight changes. |