| Main Title |
Dermal absorption of 14C-labeled 4,4'-methylenedianiline (4,4'-MDA) in rats, guinea pigs, and monkeys : final report / |
| Author |
El-Hawari, M. ;
Stoltz, M. ;
Czarnecki, D. ;
Alm, P.
|
| Other Authors |
|
| CORP Author |
Midwest Research Inst., Kansas City, MO.;Environmental Protection Agency, Washington, DC. Office of Pesticide Programs. |
| Publisher |
U.S. Environmental Protection Agency, Office of Pesticides and Toxic Substances, Field Studies Branch, |
| Year Published |
1986 |
| Report Number |
68-02-3938; EPA 560/5-86-011; EPA-68-02-3938; MRI-8501-A(21) |
| Stock Number |
PB86-179819 |
| OCLC Number |
42843573 |
| Subjects |
Skin absorption ;
4,4p1s-methylenedianiline ;
4,41-methylenedianiline
|
| Additional Subjects |
Absorption(Biology) ;
Skin(Anatomy) ;
Rats ;
Guinea pigs ;
Monkeys ;
Laboratory animals ;
Measurement ;
Therapy ;
Dosage ;
Methylenedianiline ;
Dermal absorption
|
| Internet Access |
|
| Local Library Info |
| Library |
Local Subject |
Local Note |
| N/A |
CAS No. 101-77-9 ; (4,4'-MDA); diaminodiphenylmethane; MDA |
|
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 560-5-86-011 |
|
Headquarters Library/Washington,DC |
05/04/2015 |
| ELBD ARCHIVE |
EPA 560-5-86-011 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| NTIS |
PB86-179819 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
1 volume (various pagings) : tables ; 28 cm |
| Abstract |
To help determine workplace exposure to 4,4'-MDA, studies were performed in male rats, guinea pigs and monkeys treated topically with a low (2 mg/kg) or high (20 mg/kg) dose of 14C-4,4'-MDA. Conditions of treatment (dosage, dose regimens, and occlusion) were assessed. The disposition of 4,4'-MDA was also examined after i.v. dosing. In rats, 43 and 10% of the low dose was recovered in urine and feces during a 96 h period; 2% remained in tissues and skin washing removed 25% of dose. The remainder (26%) was recovered by skin extraction and solubilization. The percent of dose absorbed decreased by increasing the dose, but the total amount absorbed (approx. 0.25 mg/rat) was similar after both doses. In g. pigs, 10 and 18% of the low dose was excreted in urine and feces; 1% was recovered in tissue, 41% in the skin wash and 29% from the application area. The percent of dose absorbed decreased following the high dose, but the amounts absorbed (in mg/animal) doubled. |
| Notes |
"January 15, 1986." "EPA Prime Contract no. 68-02-3938." "MRI Project No. 8501-A(21)." |
