Record Display for the EPA National Library Catalog


Main Title Neonatal Sympathectomy Compromises Development of Responses of Ornithine Decarboxylase to Hormonal Stimulation in Peripheral Tissues.
Author Hou, Q. C. ; Eylers, J. P. ; Lappi, S. E. ; Kavlock, R. J. ; Slotkin, T. A. ;
CORP Author Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA-R-813769; EPA/600/J-89/380;
Stock Number PB90-216193
Additional Subjects Hormones ; Kidney ; Heart ; Lung ; Angiotensin ; Vasopressin ; Graphs(Charts) ; Reprints ; Chemical sympathectomy ; Ornithine decarboxylase ; Newborn animals ; Denervation ; Hydroxydopamines
Library Call Number Additional Info Location Last
NTIS  PB90-216193 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
The onset of sympathetic innervation has been shown to play a role in the development of postsynaptic reactivity to stimulation. In the current study, whether this relationship extends to responses evoked by hormonal stimuli was examined. Rats denervated at birth by 6-hydroxydopamine treatment showed an impaired ability of vasopressin or angiotensin to stimulate cardiac ornithine decarboxylase activity. In the kidney, responsiveness was affected only for vasopressin and in the lung denervation had only transient effects on the hormonal responses. The results confirm that sympathetic input is required for proper development of some, but not all hormonal responses; the tissue specificity suggests a role of neural factors selective for cardiac development. (Copyright (c) Oxford University Press 1989.)