| Main Title |
Nuclear receptors in drug metabolism / |
| Other Authors |
|
| Publisher |
John Wiley & Sons, |
| Year Published |
2009 |
| OCLC Number |
230180300 |
| ISBN |
0470086793 (cloth); 9780470086797 (cloth) |
| Subjects |
Drugs--Metabolism ;
Nuclear receptors (Biochemistry) ;
Genetic regulation ;
Receptors, Cytoplasmic and Nuclear--metabolism ;
Drug Delivery Systems--methods ;
Pharmaceutical Preparations--metabolism ;
Receptors, Steroid--metabolism
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EKBM |
RM301.55.N83 2009 |
|
Research Triangle Park Library/RTP, NC |
11/30/2009 |
|
| Collation |
xxii, 330 p., [8] p. of plates : ill. (some col.) ; 25 cm. |
| Notes |
Includes bibliographical references and index. |
| Contents Notes |
Drug metabolism : significance and challenges -- Establishing orphan nuclear receptors PXR and CAR as xenobiotic receptors -- Nuclear receptor-mediated regulation of phase II conjugating enzymes -- Nuclear receptor-mediated regulation of drug transporters -- Structure and function of PXR and CAR -- Xenobiotic receptor cofactors and coregulators -- Animal models of xenobiotic nuclear receptors and their utility in drug development -- Nuclear receptors and drug-drug interactions of prescription drugs and herbal medicines -- Genetic variants of xenobiotic receptors and their implications in drug metabolism and pharmacogenetics -- Beyond PXR and CAR, regulation of xenobiotic metabolism by other nuclear receptors -- Emerging role of retinoid-related orphan receptor (ROR) and its cross talk with LXR (liver X receptor) in the regulation of drug-metabolizing enzymes. |
