Record Display for the EPA National Library Catalog


Main Title Nuclear receptors in drug metabolism /
Other Authors
Author Title of a Work
Xie, Wen,
Publisher John Wiley & Sons,
Year Published 2009
OCLC Number 230180300
ISBN 0470086793 (cloth); 9780470086797 (cloth)
Subjects Drugs--Metabolism ; Nuclear receptors (Biochemistry) ; Genetic regulation ; Receptors, Cytoplasmic and Nuclear--metabolism ; Drug Delivery Systems--methods ; Pharmaceutical Preparations--metabolism ; Receptors, Steroid--metabolism
Library Call Number Additional Info Location Last
EKBM  RM301.55.N83 2009 Research Triangle Park Library/RTP, NC 11/30/2009
Collation xxii, 330 p., [8] p. of plates : ill. (some col.) ; 25 cm.
Includes bibliographical references and index.
Contents Notes
Drug metabolism : significance and challenges -- Establishing orphan nuclear receptors PXR and CAR as xenobiotic receptors -- Nuclear receptor-mediated regulation of phase II conjugating enzymes -- Nuclear receptor-mediated regulation of drug transporters -- Structure and function of PXR and CAR -- Xenobiotic receptor cofactors and coregulators -- Animal models of xenobiotic nuclear receptors and their utility in drug development -- Nuclear receptors and drug-drug interactions of prescription drugs and herbal medicines -- Genetic variants of xenobiotic receptors and their implications in drug metabolism and pharmacogenetics -- Beyond PXR and CAR, regulation of xenobiotic metabolism by other nuclear receptors -- Emerging role of retinoid-related orphan receptor (ROR) and its cross talk with LXR (liver X receptor) in the regulation of drug-metabolizing enzymes.