Record Display for the EPA National Library Catalog


Main Title Hepatotoxic Interactions of Ethanol with Allyl Alcohol or Carbon Tetrachloride in Rats.
Author Berman, E. ; House, D. E. ; Allis, J. W. ; Simmons, J. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/443;
Stock Number PB93-141422
Additional Subjects Toxicity ; Ethyl alcohol ; Allyl alcohols ; Carbon tetrachloride ; Liver function tests ; Rats ; Statistical analysis ; Drug delivery systems ; Necrosis ; Multivariate analysis ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-141422 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
To assess interactive toxicity following subacute, concurrent chemical exposure, male Fischer-344 rats, approximately 70 days of age, were given ethanol at 0, 0.05, 0.1, 0.2, or 0.5 ml/kg in corn oil daily by gavage for 14 days (ETOH) group), or the same levels of ethanol with 21 mg of allyl alcohol/kg (ALAC group), or the same levels of ethanol with 20 mg of carbon tetrachloride/kg (CCL4 group). Hepatic response was assessed 24 hr after the last dose. Interactions were evaluated by comparing the ETOH group with either the ALAC group or the CCL4 group using multivariate analysis of variance procedures. No statistically significant interaction was seen between the ETOH group and the ALAC group at the dosages used.