Record Display for the EPA National Library Catalog
RECORD NUMBER: 4 OF 22| Main Title | Evaluation of the potential carcinogenicity of dinitrotoluene (mixture) (25321-14-6) / | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CORP Author | Syracuse Research Corp., NY. ;Environmental Monitoring and Services, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. | |||||||||||
| Publisher | U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ; | |||||||||||
| Year Published | 1988 | |||||||||||
| Report Number | EPA/600/8-91/122; EPA-68-03-3112; EPA-68-03-3182; OHEA-C-073-097 | |||||||||||
| Stock Number | PB93-185395 | |||||||||||
| Subjects | Dinotrotoluene--Carcinogenicity | |||||||||||
| Additional Subjects | Toxicity ; Risk assessment ; Exposure ; Public health ; Hazardous materials ; Neoplasms ; Tolerances(Physiology) ; DNT(Dinitrotoluenes) ; Carcinogenicity ; Dose-response relationships ; CAS Registry No: 25321-14-6 | |||||||||||
| Holdings |
|
|||||||||||
| Collation | 19 pages ; 28 cm | |||||||||||
| Abstract | Carcinogenicity data for mixed dinitrotoluenes are inadequate. Since the technical grade mixture consists of approximately 75 percent 2,4-dinitrotoluene and 19.5 percent 2,6-dinitrotoluene, hazard assessment for the mixture can be based on experimentation with the 2,4-isomer. Dinitrotoluene (mixture) is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment. Evidence on potential carcinogenicity from animal studies is Sufficient, and the evidence from human studies is No Data. The potency factor (F) for dinitrotoluene (mixed) is the same as the factor for 2,4-dinitrotoluene, which is 3,82 (mg/kg/day)(-1). Therefore, dinitrotoluene (mixture) can be placed in potency group 2 according to the CAG's methodology for evaluating potential carcinogens. Combining the weight-of-evidence group and the potency group, dinitrotoluene (mixture) is assigned a MEDIUM hazard ranking. |
|||||||||||
| Notes | Cover title. "June 1988." Includes bibliographical references. Microfiche. |