| Contents Notes |
This report summarizes the literature concerning adducts formed by xenobiotics with DNA and protein in order to determine their feasibility as a monitoring tool for use in exposure and risk assessment and to propose compounds and methods that may be appropriate for preliminary field studies. This report is divided into three segments. The first segment provides an introduction to DNA damage and its relation to carcinogenesis. This segment also discusses available methodology for the measurement of macromolecular (DNA, protein) adducts. The techniques were evaluated according to their sensitivity, selectivity, limitations, and future possibilities. The next segment provides a summary of the current literature on the individual chemicals found to form adducts in both man and in experimental animals. The information in this segment and additional information was tabulated and is presented in the appendix. Finally, the conclusion and recommendation section discusses the overall potential for the use of macromolecular adducts as a measure of dose, given the current technology. Recommendations on the analytical detection methodologies, applicable chemicals, and populations to be used for a human monitoring pilot study were offered. |
