Record Display for the EPA National Library Catalog

RECORD NUMBER: 13 OF 17

Main Title Route of Absorption of DDVP after Oral Administration to Rats.
Author Laws, Jr., Edward R. ;
CORP Author Communicable Disease Center, Atlanta, Ga.
Year Published 1965
Stock Number PB-278 091
Additional Subjects Absorption(Biology) ; Pesticides ; Toxicology ; Insecticides ; Ingestion(Biology) ; Rats ; Chlorine organic compounds ; Experimental data ; Tables(Data) ; Laboratory animals ; Blood chemical analysis ; Metabolism ; Liver ; Detoxification ; Bioassay ; Reprints ; DDVP insecticide ; Toxic substances
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB-278 091 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 4p
Abstract
Ten rats were infused by stomach tube with radioactive DDVP while timed samples of portal blood, systemic venous blood, and chyle were taken. Levels of DDVP were determined in all samples and were found to be much higher in portal blood than in either systemic blood or chyle. They were slightly higher in systemic blood than in chyle. It is felt that these findings support the hypothesis that, in the rat, DDVP taken orally is absorbed primarily if not exclusively by the hepatic portal venous system, and, therefore, is routed through the detoxification processes of the liver before reaching the systemic circulation.