Cell Cycle Activation in Neurons -- Paved with Good Intentions -- The Role of Presenilins in the Cell Cycle and Apoptosis -- Cell Cycle Activation and Cell Death in the Nervous System -- Cell Cycle and Chromosome Segregation Defects in Alzheimer's Disease -- Alzheimer Disease -- From Cell Cycle Activation to the Inhibition of the Wnt Pathway. Cell-Cycle Mechanisms and Neuronal Cell Death examines the role of cell cycle activation in the molecular mechanisms leading to neuronal degeneration. Leading Authors discuss this topic in relation to the major neurological disorders, including Alzheimer's disease, stroke and epilepsy. This book serves to gain new insights into the molecular determinants of neuronal death and to establish new targets for therapeutic intervention.