Record Display for the EPA National Library Catalog

RECORD NUMBER: 29 OF 32

Main Title Synaptonemal Complex Damage as a Measure of Genotoxicity at Meiosis.
Author Allen, J. W. ; Poorman, P. A. ; Backer, L. C. ; Gibson, J. B. ; Westbrook-Collins, B. ;
CORP Author Burroughs Wellcome Co., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1988
Report Number EPA-R-812736; EPA/600/D-88/136;
Stock Number PB88-223789
Additional Subjects Toxicity ; Genes ; Meiosis ; Cell division ; Chromosomes ; Mitomycins ; Cyclophosphamide ; Colchicine ; Vinblastine ; Laboratory animals ; Mice ; Chromosomal aberrations ; Genetic disorders ; Genotoxicity ; Duplication(Genes) ; Amsacrine ; Ellipticines ; Cisplatin ; Chromosome damage ; Synaptonemal complex
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB88-223789 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
Abstract
Synaptonemal complex aberrations can provide a sensitive measure of chemical-specific alterations to meiotic chromosomes. Mitomycin C, cyclophosphamide, amsacrine, ellipticine, colchicine, vinblastine sulfate, and cis-platin exposures in mice have been shown to cause various patterns of synaptonemal complex structural damage and synaptic irregularity. These effects are suggestive of abnormal homologue pairing/synapsis/recombination effects which, theoretically, could be implicated in mechanisms leading to aneuploidy and other potentially heritable chromosomal disorders.