Record Display for the EPA National Library Catalog

RECORD NUMBER: 14 OF 32

Main Title Evaluation of the potential carcinogenicity of cyclophosphamide (50-18-01) /
CORP Author Syracuse Research Corp., NY. ;Environmental Monitoring and Services, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ;
Year Published 1988
Report Number EPA/600/8-91/097; EPA-68-03-3112; EPA-68-03-3182
Stock Number PB93-185189
Subjects Aromatic compounds--Carcinogenicity ; Cyclophosphamide--Carcinogenicity
Additional Subjects Carcinogens ; Toxicity ; Cyclophosphamide ; Risk assessment ; Humans ; Animals ; Dose-response relationships ; Carcinogenicity tests ; CAS 50-18-0
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB93-185189 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 24 pages ; 28 cm
Abstract
Cyclophosphamide is a probable human carcinogen, classified as weight-of-evidence Group B1 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on potential carcinogenicity from animal studies is Sufficient, and the evidence from human studies is Limited. The potency factor (F) for cyclophosphamide is estimated to be 17.5/(mg/kg/day), placing it in potency group 2 according to the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986b). Combining the weight-of-evidence group and the potency group, cyclophosphamide is assigned a MEDIUM hazard ranking for the purposes of RQ adjustment.
Notes
Cover title. "June 1988." Includes bibliographical references. Microfiche.